Title : Metformin increases APP expression and processing via oxidative stress, mitochondrial dysfunction and NF-κB activation: Use of insulin to attenuate metformin's effect.

Pub. Date : 2015 May

PMID : 25667085






2 Functional Relationships(s)
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1 This study demonstrates the effect of metformin, a therapeutic biguanide administered for T2DM therapy, on beta-amyloid precursor protein (APP) metabolism in in vitro, ex vivo and in vivo models. Metformin amyloid beta precursor protein Homo sapiens
2 These effects of metformin were found to be antagonized by the addition of insulin, which reduced Abeta levels, oxidative stress, mitochondrial dysfunction and cell death. Metformin amyloid beta precursor protein Homo sapiens