Pub. Date : 2015 May
PMID : 25667085
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | This study demonstrates the effect of metformin, a therapeutic biguanide administered for T2DM therapy, on beta-amyloid precursor protein (APP) metabolism in in vitro, ex vivo and in vivo models. | Metformin | amyloid beta precursor protein | Homo sapiens |
2 | These effects of metformin were found to be antagonized by the addition of insulin, which reduced Abeta levels, oxidative stress, mitochondrial dysfunction and cell death. | Metformin | amyloid beta precursor protein | Homo sapiens |