PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25667085-2 2015 This study demonstrates the effect of metformin, a therapeutic biguanide administered for T2DM therapy, on beta-amyloid precursor protein (APP) metabolism in in vitro, ex vivo and in vivo models. Metformin 38-47 amyloid beta precursor protein Homo sapiens 107-137 25667085-8 2015 These effects of metformin were found to be antagonized by the addition of insulin, which reduced Abeta levels, oxidative stress, mitochondrial dysfunction and cell death. Metformin 17-26 amyloid beta precursor protein Homo sapiens 98-103