Pub. Date : 2015 Sep
PMID : 25655087
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Further study revealed that ALA exerted its bone-protective effects by inhibiting reactive oxygen species (ROS) generation by down-regulating Nox4 gene expression and protein synthesis and attenuating the transcriptional activation of NF-kappaB. | Thioctic Acid | NADPH oxidase 4 | Rattus norvegicus |
| 2 | Taken together, the present study indicated that ALA promoted osteoblastic formation in H(2)O(2) -treated MC3T3-E1 cells and prevented OVX-induced bone loss in rats by regulating Nox4/ROS/NF-kappaB and Wnt/Lrp5/beta-catenin signaling pathways, which provided possible mechanisms of bone-protective effects in regulating osteoblastic formation and preventing bone loss. | Thioctic Acid | NADPH oxidase 4 | Rattus norvegicus |