Pub. Date : 2015 Jan 27
PMID : 25622857
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Activation of the NF-kappaB pathway as a mechanism of alcohol enhanced progression and metastasis of human hepatocellular carcinoma. | Alcohols | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | Consistently, higher expression of VEGF, MCP-1 and NF-kappaB was observed in HCC tissues of alcohol-drinkers. | Alcohols | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | Alcohol induced the accumulation of intracellular reactive oxygen species (ROS) and the activation of NF-kappaB signaling in HepG2 cells. | Alcohols | nuclear factor kappa B subunit 1 | Homo sapiens |
| 4 | Conversely, blockage of alcohol-mediated ROS accumulation and NF-kappaB signaling inhibited alcohol-induced expression of VEGF and MCP-1, the tumor growth, angiogenesis and metastasis. | Alcohols | nuclear factor kappa B subunit 1 | Homo sapiens |