Title : Ketamine treatment partly reverses alterations in brain derived- neurotrophic factor, oxidative stress and energy metabolism parameters induced by an animal model of depression.

Pub. Date : 2015

PMID : 25613382






3 Functional Relationships(s)
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1 Ketamine treatment partly reverses alterations in brain derived- neurotrophic factor, oxidative stress and energy metabolism parameters induced by an animal model of depression. Ketamine brain-derived neurotrophic factor Rattus norvegicus
2 In the amygdala, hippocampus and nucleus accumbens (NAc), a reduction in BDNF levels was observed in deprived rats, but the animals treated with ketamine reversed the effects of this animal model only in the amygdala and NAc. Ketamine brain-derived neurotrophic factor Rattus norvegicus
3 These findings may help to explain that dysfunctions involving BDNF, oxidative stress and energy metabolism within specific brain areas, may be linked with the pathophysiology of depression, and antidepressant effects of ketamine can be positive, at least partially due to the control of these pathways. Ketamine brain-derived neurotrophic factor Rattus norvegicus