Pub. Date : 2015 Apr
PMID : 25575548
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CONCLUSIONS: Three LoF mutations in HAL were associated with increased histidine levels, which in turn were shown to be inversely related to the risk of CHD among both African Americans and European Americans. | Histidine | histidine ammonia-lyase | Homo sapiens |
| 2 | METHODS AND RESULTS: By conducting whole exome sequencing on 1152 African Americans in the Atherosclerosis Risk in Communities (ARIC) study and focusing on loss-of-function (LoF) variants, we identified 3 novel rare LoF variants in HAL, a gene that encodes histidine ammonia-lyase in the first step of histidine catabolism. | Histidine | histidine ammonia-lyase | Homo sapiens |