PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25575548-9 2015 CONCLUSIONS: Three LoF mutations in HAL were associated with increased histidine levels, which in turn were shown to be inversely related to the risk of CHD among both African Americans and European Americans. Histidine 71-80 histidine ammonia-lyase Homo sapiens 36-39 25575548-3 2015 METHODS AND RESULTS: By conducting whole exome sequencing on 1152 African Americans in the Atherosclerosis Risk in Communities (ARIC) study and focusing on loss-of-function (LoF) variants, we identified 3 novel rare LoF variants in HAL, a gene that encodes histidine ammonia-lyase in the first step of histidine catabolism. Histidine 257-266 histidine ammonia-lyase Homo sapiens 232-235