Pub. Date : 2015 Aug
PMID : 25546515
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The present study investigated the possible involvement of the cystic fibrosis transmembrane conductance regulator (CFTR), which has been previously shown to negatively regulate nuclear factor-kappaB (NF-kappaB)/cyclooxygenase 2 (COX2)/prostaglandin E2 (PGE2) pathway, in the pathogenesis of BPH. | Dinoprostone | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | The present study investigated the possible involvement of the cystic fibrosis transmembrane conductance regulator (CFTR), which has been previously shown to negatively regulate nuclear factor-kappaB (NF-kappaB)/cyclooxygenase 2 (COX2)/prostaglandin E2 (PGE2) pathway, in the pathogenesis of BPH. | Dinoprostone | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | Furthermore, suppression of CFTR led to increased expression of COX2 and over-production of PGE2 in a normal human prostate epithelial cell line (PNT1A) with elevated NF-kappaB activity. | Dinoprostone | nuclear factor kappa B subunit 1 | Homo sapiens |
| 4 | The present results suggest that CFTR may be involved in regulating PGE2 production through its negative regulation on NF-kappaB/COX2 pathway in prostate epithelial cells, which consequently stimulates cell growth of prostate stromal cells. | Dinoprostone | nuclear factor kappa B subunit 1 | Homo sapiens |