PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25546515-2	2015	The present study investigated the possible involvement of the cystic fibrosis transmembrane conductance regulator (CFTR), which has been previously shown to negatively regulate nuclear factor-kappaB (NF-kappaB)/cyclooxygenase 2 (COX2)/prostaglandin E2 (PGE2) pathway, in the pathogenesis of BPH.	Dinoprostone	236-252	nuclear factor kappa B subunit 1	Homo sapiens	201-210	
25546515-2	2015	The present study investigated the possible involvement of the cystic fibrosis transmembrane conductance regulator (CFTR), which has been previously shown to negatively regulate nuclear factor-kappaB (NF-kappaB)/cyclooxygenase 2 (COX2)/prostaglandin E2 (PGE2) pathway, in the pathogenesis of BPH.	Dinoprostone	254-258	nuclear factor kappa B subunit 1	Homo sapiens	201-210	
25546515-4	2015	Furthermore, suppression of CFTR led to increased expression of COX2 and over-production of PGE2 in a normal human prostate epithelial cell line (PNT1A) with elevated NF-kappaB activity.	Dinoprostone	92-96	nuclear factor kappa B subunit 1	Homo sapiens	167-176	
25546515-8	2015	The present results suggest that CFTR may be involved in regulating PGE2 production through its negative regulation on NF-kappaB/COX2 pathway in prostate epithelial cells, which consequently stimulates cell growth of prostate stromal cells.	Dinoprostone	68-72	nuclear factor kappa B subunit 1	Homo sapiens	119-128