Title : Downregulation of beta-adrenergic receptor-mediated function during sodium restriction in humans.

Pub. Date : 1989 Oct

PMID : 2552821






2 Functional Relationships(s)
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1 Sodium restriction resulted in an increase in the plasma NE concentration (P less than 0.02) and decreases in MNL beta 2-AR density (P less than 0.001), affinity for antagonist (P less than 0.001), and adenylate cyclase sensitivity to isoproterenol (ANOVA, P less than 0.01). Sodium adrenoceptor beta 2 Homo sapiens
2 Our data suggest that the downregulation of MNL beta 2-AR-mediated function in humans during dietary sodium restriction is a response to the increase in plasma NE. Sodium adrenoceptor beta 2 Homo sapiens