Title : Glucose intolerance in aging male IGFBP-3 transgenic mice: differential effects of human IGFBP-3 and its mutant IGFBP-3 devoid of IGF binding ability.

Pub. Date : 2015 Feb

PMID : 25490144






1 Functional Relationships(s)
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1 Thus, overexpression of human IGFBP-3 or its mutant devoid of IGF binding ability leads to glucose intolerance with, however, different effects on insulin secretion, insulin sensitivity, and lipid homeostasis in aging mice. Glucose insulin like growth factor binding protein 3 Homo sapiens