Pub. Date : 2015 Feb
PMID : 25477161
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A NOS3 polymorphism determines endothelial response to folate in children with type 1 diabetes or obesity. | Folic Acid | nitric oxide synthase 3 | Homo sapiens |
| 2 | OBJECTIVE: To determine the effect of polymorphisms in NOS3 and folate pathway enzymes on vascular function and folate status and endothelial response to folate in children with diabetes or obesity. | Folic Acid | nitric oxide synthase 3 | Homo sapiens |
| 3 | OBJECTIVE: To determine the effect of polymorphisms in NOS3 and folate pathway enzymes on vascular function and folate status and endothelial response to folate in children with diabetes or obesity. | Folic Acid | nitric oxide synthase 3 | Homo sapiens |
| 4 | The effect of NOS3 genotype on endothelial response to folate (5 mg) was assessed in 85 subjects with diabetes and 28 obese subjects who received active treatment during intervention trials. | Folic Acid | nitric oxide synthase 3 | Homo sapiens |
| 5 | The polymorphism in intron 4 of endothelial nitric oxide synthase altered endothelial response to folate significantly: in subjects with diabetes FMD improved by 6.4 +- 5% (insertion carriers) vs 2.3 +- 6.6% (deletion carriers), P = .01; in obese subjects FMD improved by 1.8 +- 5.4% (insertion carriers) and deteriorated by -3.2 +- 7.2% (deletion carriers), P = .05. | Folic Acid | nitric oxide synthase 3 | Homo sapiens |
| 6 | CONCLUSIONS: A NOS3 polymorphism predicts endothelial response to folate in children with diabetes or obesity, with implications for vascular risk and folate intervention studies. | Folic Acid | nitric oxide synthase 3 | Homo sapiens |
| 7 | CONCLUSIONS: A NOS3 polymorphism predicts endothelial response to folate in children with diabetes or obesity, with implications for vascular risk and folate intervention studies. | Folic Acid | nitric oxide synthase 3 | Homo sapiens |