PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25477161-0	2015	A NOS3 polymorphism determines endothelial response to folate in children with type 1 diabetes or obesity.	Folic Acid	55-61	nitric oxide synthase 3	Homo sapiens	2-6	
25477161-1	2015	OBJECTIVE: To determine the effect of polymorphisms in NOS3 and folate pathway enzymes on vascular function and folate status and endothelial response to folate in children with diabetes or obesity.	Folic Acid	112-118	nitric oxide synthase 3	Homo sapiens	55-59	
25477161-1	2015	OBJECTIVE: To determine the effect of polymorphisms in NOS3 and folate pathway enzymes on vascular function and folate status and endothelial response to folate in children with diabetes or obesity.	Folic Acid	112-118	nitric oxide synthase 3	Homo sapiens	55-59	
25477161-3	2015	The effect of NOS3 genotype on endothelial response to folate (5 mg) was assessed in 85 subjects with diabetes and 28 obese subjects who received active treatment during intervention trials.	Folic Acid	55-61	nitric oxide synthase 3	Homo sapiens	14-18	
25477161-6	2015	The polymorphism in intron 4 of endothelial nitric oxide synthase altered endothelial response to folate significantly: in subjects with diabetes FMD improved by 6.4 +- 5% (insertion carriers) vs 2.3 +- 6.6% (deletion carriers), P = .01; in obese subjects FMD improved by 1.8 +- 5.4% (insertion carriers) and deteriorated by -3.2 +- 7.2% (deletion carriers), P = .05.	Folic Acid	98-104	nitric oxide synthase 3	Homo sapiens	32-65	
25477161-8	2015	CONCLUSIONS: A NOS3 polymorphism predicts endothelial response to folate in children with diabetes or obesity, with implications for vascular risk and folate intervention studies.	Folic Acid	66-72	nitric oxide synthase 3	Homo sapiens	15-19	
25477161-8	2015	CONCLUSIONS: A NOS3 polymorphism predicts endothelial response to folate in children with diabetes or obesity, with implications for vascular risk and folate intervention studies.	Folic Acid	151-157	nitric oxide synthase 3	Homo sapiens	15-19