Title : The cytotoxic effects of estradiol-17 beta, catecholestradiols and methoxyestradiols on dividing MCF-7 and HeLa cells.

Pub. Date : 1989 Jun

PMID : 2547112






1 Functional Relationships(s)
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1 The reduction in the number of HeLa cells with abnormal metaphase configurations after exposure to 2-OHE2 plus quinalizarin (an inhibitor of catechol-O-methyltransferase) indicated that the production of 2-MeOE2 is necessary for the formation of abnormal spindles in metaphase. 2-hydroxyestradiol catechol-O-methyltransferase Homo sapiens