Title : Parthenolide inhibits pro-inflammatory cytokine production and exhibits protective effects on progression of collagen-induced arthritis in a rat model.

Pub. Date : 2015 May

PMID : 25439190






2 Functional Relationships(s)
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1 RESULTS: We established that PAR, as a prototype compound, suppressed lipopolysaccharide (LPS)- and tumour necrosis factor (TNF)-alpha-induced increases in matrix metalloproteinase (MMP)-1, MMP-3, inducible nitric oxide synthase (iNOS), and interleukin (IL)-1beta mRNA in chondrocytes. parthenolide nitric oxide synthase 2 Rattus norvegicus
2 RESULTS: We established that PAR, as a prototype compound, suppressed lipopolysaccharide (LPS)- and tumour necrosis factor (TNF)-alpha-induced increases in matrix metalloproteinase (MMP)-1, MMP-3, inducible nitric oxide synthase (iNOS), and interleukin (IL)-1beta mRNA in chondrocytes. parthenolide nitric oxide synthase 2 Rattus norvegicus