Pub. Date : 2014
PMID : 25400722
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Curcumin inhibits oral squamous cell carcinoma proliferation and invasion via EGFR signaling pathways. | Curcumin | epidermal growth factor receptor | Homo sapiens |
| 2 | Curcumin is known to inhibit growth, invasion and metastasis by downregulating EGFR expression in some cancer cells. | Curcumin | epidermal growth factor receptor | Homo sapiens |
| 3 | We also explored the effect of curcumin on the activition of EGFR and its downstream signaling molecules Akt, ERK1/2 and STAT3. | Curcumin | epidermal growth factor receptor | Homo sapiens |
| 4 | Furthermore, we examined the inhibition effect of curcumin on EGF-induced EGFR phosphorylation and SCC-25 cells invasion. | Curcumin | epidermal growth factor receptor | Homo sapiens |
| 5 | We further revealed that curcumin regulated the p-EGFR and EGFR downstream signaling molecules including Akt, ERK1/2 and STAT3. | Curcumin | epidermal growth factor receptor | Homo sapiens |
| 6 | We further revealed that curcumin regulated the p-EGFR and EGFR downstream signaling molecules including Akt, ERK1/2 and STAT3. | Curcumin | epidermal growth factor receptor | Homo sapiens |
| 7 | Taken together, our results suggest that curcumin reduced SCC-25 cells proliferation and invasion through inhibiting the phosphorylation of EGFR and EGFR downstream signaling molecules Akt, ERK1/2 and STAT3. | Curcumin | epidermal growth factor receptor | Homo sapiens |
| 8 | Taken together, our results suggest that curcumin reduced SCC-25 cells proliferation and invasion through inhibiting the phosphorylation of EGFR and EGFR downstream signaling molecules Akt, ERK1/2 and STAT3. | Curcumin | epidermal growth factor receptor | Homo sapiens |