PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25400722-0 2014 Curcumin inhibits oral squamous cell carcinoma proliferation and invasion via EGFR signaling pathways. Curcumin 0-8 epidermal growth factor receptor Homo sapiens 78-82 25400722-2 2014 Curcumin is known to inhibit growth, invasion and metastasis by downregulating EGFR expression in some cancer cells. Curcumin 0-8 epidermal growth factor receptor Homo sapiens 79-83 25400722-5 2014 We also explored the effect of curcumin on the activition of EGFR and its downstream signaling molecules Akt, ERK1/2 and STAT3. Curcumin 31-39 epidermal growth factor receptor Homo sapiens 61-65 25400722-6 2014 Furthermore, we examined the inhibition effect of curcumin on EGF-induced EGFR phosphorylation and SCC-25 cells invasion. Curcumin 50-58 epidermal growth factor receptor Homo sapiens 74-78 25400722-9 2014 We further revealed that curcumin regulated the p-EGFR and EGFR downstream signaling molecules including Akt, ERK1/2 and STAT3. Curcumin 25-33 epidermal growth factor receptor Homo sapiens 50-54 25400722-9 2014 We further revealed that curcumin regulated the p-EGFR and EGFR downstream signaling molecules including Akt, ERK1/2 and STAT3. Curcumin 25-33 epidermal growth factor receptor Homo sapiens 59-63 25400722-11 2014 Taken together, our results suggest that curcumin reduced SCC-25 cells proliferation and invasion through inhibiting the phosphorylation of EGFR and EGFR downstream signaling molecules Akt, ERK1/2 and STAT3. Curcumin 41-49 epidermal growth factor receptor Homo sapiens 140-144 25400722-11 2014 Taken together, our results suggest that curcumin reduced SCC-25 cells proliferation and invasion through inhibiting the phosphorylation of EGFR and EGFR downstream signaling molecules Akt, ERK1/2 and STAT3. Curcumin 41-49 epidermal growth factor receptor Homo sapiens 149-153