Title : Celastrol stimulates hypoxia-inducible factor-1 activity in tumor cells by initiating the ROS/Akt/p70S6K signaling pathway and enhancing hypoxia-inducible factor-1α protein synthesis.

Pub. Date : 2014

PMID : 25383959






2 Functional Relationships(s)
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Compound Name
Protein Name
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1 Celastrol stimulates hypoxia-inducible factor-1 activity in tumor cells by initiating the ROS/Akt/p70S6K signaling pathway and enhancing hypoxia-inducible factor-1alpha protein synthesis. celastrol ribosomal protein S6 kinase B1 Homo sapiens
2 Instead, Celastrol induced the accumulation of the HIF-1alpha protein by inducing ROS and activating Akt/p70S6K signaling to promote HIF-1alpha translation. celastrol ribosomal protein S6 kinase B1 Homo sapiens