Pub. Date : 2015 Mar
PMID : 25262246
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cannabinoid receptor CB1 is involved in nicotine-induced protection against Abeta1-42 neurotoxicity in HT22 cells. | Nicotine | cannabinoid receptor 1 (brain) | Mus musculus |
| 2 | We hypothesized that cannabinoid receptor CB1 is involved in the nicotine-induced neuroprotection against Abeta1-42 injury in HT22 cells. | Nicotine | cannabinoid receptor 1 (brain) | Mus musculus |
| 3 | The results demonstrated that nicotine markedly upregulated CB1 expression, increased cell viability, ameliorated cellular morphology, decreased LDH release, and reduced the apoptotic rate of HT22 cells exposed to Abeta1-42 for 24 h, while the blockade of CB1 or the inhibition of protein kinase C (PKC) partially reversed the neuroprotection. | Nicotine | cannabinoid receptor 1 (brain) | Mus musculus |
| 4 | The results demonstrated that nicotine markedly upregulated CB1 expression, increased cell viability, ameliorated cellular morphology, decreased LDH release, and reduced the apoptotic rate of HT22 cells exposed to Abeta1-42 for 24 h, while the blockade of CB1 or the inhibition of protein kinase C (PKC) partially reversed the neuroprotection. | Nicotine | cannabinoid receptor 1 (brain) | Mus musculus |
| 5 | Furthermore, the blockade of CB1 reversed nicotine-induced PKC activation in HT22 cells exposed to Abeta1-42. | Nicotine | cannabinoid receptor 1 (brain) | Mus musculus |
| 6 | These results suggest that CB1 is involved in the nicotine-induced neuroprotection against Abeta1-42 neurotoxicity, and the neuroprotection may be dependent on the activation of PKC. | Nicotine | cannabinoid receptor 1 (brain) | Mus musculus |