Title : Cannabinoid receptor CB1 is involved in nicotine-induced protection against Aβ1-42 neurotoxicity in HT22 cells.

Pub. Date : 2015 Mar

PMID : 25262246






6 Functional Relationships(s)
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1 Cannabinoid receptor CB1 is involved in nicotine-induced protection against Abeta1-42 neurotoxicity in HT22 cells. Nicotine cannabinoid receptor 1 (brain) Mus musculus
2 We hypothesized that cannabinoid receptor CB1 is involved in the nicotine-induced neuroprotection against Abeta1-42 injury in HT22 cells. Nicotine cannabinoid receptor 1 (brain) Mus musculus
3 The results demonstrated that nicotine markedly upregulated CB1 expression, increased cell viability, ameliorated cellular morphology, decreased LDH release, and reduced the apoptotic rate of HT22 cells exposed to Abeta1-42 for 24 h, while the blockade of CB1 or the inhibition of protein kinase C (PKC) partially reversed the neuroprotection. Nicotine cannabinoid receptor 1 (brain) Mus musculus
4 The results demonstrated that nicotine markedly upregulated CB1 expression, increased cell viability, ameliorated cellular morphology, decreased LDH release, and reduced the apoptotic rate of HT22 cells exposed to Abeta1-42 for 24 h, while the blockade of CB1 or the inhibition of protein kinase C (PKC) partially reversed the neuroprotection. Nicotine cannabinoid receptor 1 (brain) Mus musculus
5 Furthermore, the blockade of CB1 reversed nicotine-induced PKC activation in HT22 cells exposed to Abeta1-42. Nicotine cannabinoid receptor 1 (brain) Mus musculus
6 These results suggest that CB1 is involved in the nicotine-induced neuroprotection against Abeta1-42 neurotoxicity, and the neuroprotection may be dependent on the activation of PKC. Nicotine cannabinoid receptor 1 (brain) Mus musculus