Title : Induction of glutathione synthesis in human hepatocytes by acute and chronic arsenic exposure: differential roles of mitogen-activated protein kinases.

Pub. Date : 2014 Nov 5

PMID : 25201354






2 Functional Relationships(s)
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1 We found that acute arsenic exposure activated extracellular signal-regulated 1/2 kinases (ERK1/2) and c-Jun N-terminal kinase (JNK) in parallel with increased transcription and nuclear translocation of factor-erythroid 2-related factor 2 (NRF2) and enhanced expression of gamma-glutamyl cysteine ligase catalytic subunit (GCLC), resulting in elevated intracellular GSH levels. Arsenic mitogen-activated protein kinase 8 Homo sapiens
2 We found that acute arsenic exposure activated extracellular signal-regulated 1/2 kinases (ERK1/2) and c-Jun N-terminal kinase (JNK) in parallel with increased transcription and nuclear translocation of factor-erythroid 2-related factor 2 (NRF2) and enhanced expression of gamma-glutamyl cysteine ligase catalytic subunit (GCLC), resulting in elevated intracellular GSH levels. Arsenic mitogen-activated protein kinase 8 Homo sapiens