Pub. Date : 2014 Oct 3
PMID : 25139527
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | 7,8-dihydroxyflavone protects PC12 cells against 6-hydroxydopamine-induced cell death through modulating PI3K/Akt and JNK pathways. | Oxidopamine | mitogen-activated protein kinase 8 | Rattus norvegicus |
| 2 | Western blot analysis showed that 6-OHDA (100muM, 24h) enhanced the phosphorylation of JNK and ERK1/2, but it markedly suppressed the expression of p-Akt, implying that 6-OHDA induces PC12 cell death through activating the pro-apoptotic MAPKs pathway but suppressing the survival PI3K/Akt pathway. | Oxidopamine | mitogen-activated protein kinase 8 | Rattus norvegicus |
| 3 | Western blot analysis showed that 6-OHDA (100muM, 24h) enhanced the phosphorylation of JNK and ERK1/2, but it markedly suppressed the expression of p-Akt, implying that 6-OHDA induces PC12 cell death through activating the pro-apoptotic MAPKs pathway but suppressing the survival PI3K/Akt pathway. | Oxidopamine | mitogen-activated protein kinase 8 | Rattus norvegicus |
| 4 | These results suggest that 7,8-DHF might protect PC12 cells from 6-OHDA-induced cell death through activating PI3K/Akt pathway and inhibiting JNK pathway. | Oxidopamine | mitogen-activated protein kinase 8 | Rattus norvegicus |