PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25139527-0 2014 7,8-dihydroxyflavone protects PC12 cells against 6-hydroxydopamine-induced cell death through modulating PI3K/Akt and JNK pathways. Oxidopamine 49-66 mitogen-activated protein kinase 8 Rattus norvegicus 118-121 25139527-3 2014 Western blot analysis showed that 6-OHDA (100muM, 24h) enhanced the phosphorylation of JNK and ERK1/2, but it markedly suppressed the expression of p-Akt, implying that 6-OHDA induces PC12 cell death through activating the pro-apoptotic MAPKs pathway but suppressing the survival PI3K/Akt pathway. Oxidopamine 34-40 mitogen-activated protein kinase 8 Rattus norvegicus 87-90 25139527-3 2014 Western blot analysis showed that 6-OHDA (100muM, 24h) enhanced the phosphorylation of JNK and ERK1/2, but it markedly suppressed the expression of p-Akt, implying that 6-OHDA induces PC12 cell death through activating the pro-apoptotic MAPKs pathway but suppressing the survival PI3K/Akt pathway. Oxidopamine 169-175 mitogen-activated protein kinase 8 Rattus norvegicus 87-90 25139527-7 2014 These results suggest that 7,8-DHF might protect PC12 cells from 6-OHDA-induced cell death through activating PI3K/Akt pathway and inhibiting JNK pathway. Oxidopamine 65-71 mitogen-activated protein kinase 8 Rattus norvegicus 142-145