Pub. Date : 2014 Oct
PMID : 25082450
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Depigmentation caused by application of the active brightening material, rhododendrol, is related to tyrosinase activity at a certain threshold. | rhododendrol | tyrosinase | Homo sapiens |
| 2 | Unexpected depigmentation of the skin characterized with the diverse symptoms was reported in some subjects who used a tyrosinase-competitive inhibiting quasi-drug, rhododendrol. | rhododendrol | tyrosinase | Homo sapiens |
| 3 | The RNAi technology was utilized to confirm the effect of tyrosinase to induce the cytotoxicity of rhododendrol and liquid chromatography-tandem mass spectrometry was introduced to detect rhododendrol and its metabolites in the presence of tyrosinase. | rhododendrol | tyrosinase | Homo sapiens |
| 4 | Treatment with a tyrosinase-specific siRNA was shown to dramatically rescue the rhododendrol-induced melanocyte impairment. | rhododendrol | tyrosinase | Homo sapiens |
| 5 | CONCLUSION: The generation of a tyrosinase-catalyzed hydroxyl-metabolite is one of the causes for the diminishment of the melanocyte viability by rhododendrol. | rhododendrol | tyrosinase | Homo sapiens |