Title : The ALK inhibitor ASP3026 eradicates NPM-ALK⁺ T-cell anaplastic large-cell lymphoma in vitro and in a systemic xenograft lymphoma model.

Pub. Date : 2014 Jul 30

PMID : 25026277






1 Functional Relationships(s)
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1 In addition, ASP3026 significantly reduced the proliferation of 293T cells transfected with NPM-ALK mutants that are resistant to crizotinib and downregulated tyrosine phosphorylation of these mutants. Tyrosine ALK receptor tyrosine kinase Homo sapiens