Pub. Date : 2015 Feb 10
PMID : 24893130
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | AIMS: Cystathionine beta-synthase (CBS) catalyzes the first and rate-limiting step in the two-step trans-sulfuration pathway that converts homocysteine to cysteine. | Cysteine | cystathionine beta-synthase | Homo sapiens |
| 2 | AIMS: Cystathionine beta-synthase (CBS) catalyzes the first and rate-limiting step in the two-step trans-sulfuration pathway that converts homocysteine to cysteine. | Cysteine | cystathionine beta-synthase | Homo sapiens |
| 3 | INNOVATION: Collectively, our results reveal a novel post-translational modification of CBS, that is, glutathionylation, which functions as an allosteric activator under oxidative stress conditions permitting enhanced synthesis of both cysteine and H2S. | Cysteine | cystathionine beta-synthase | Homo sapiens |
| 4 | CONCLUSIONS: Our study elucidates a molecular mechanism for increased cysteine and therefore glutathione, synthesis via glutathionylation of CBS. | Cysteine | cystathionine beta-synthase | Homo sapiens |