Title : Effective glycaemic control critically determines insulin cardioprotection against ischaemia/reperfusion injury in anaesthetized dogs.

Pub. Date : 2014 Jul 15

PMID : 24845581

1 Functional Relationships(s)
Compound Name
Protein Name
1 In vitro mechanistic study in neonatal rat cardiomyocytes revealed that insulin-stimulated tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1) and Akt was significantly attenuated by high glucose, accompanied by markedly increased IRS-1 O-GlcNAc glycosylation following hypoxia/reoxygenation. Tyrosine insulin receptor substrate 1 Rattus norvegicus