PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24845581-8 2014 In vitro mechanistic study in neonatal rat cardiomyocytes revealed that insulin-stimulated tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1) and Akt was significantly attenuated by high glucose, accompanied by markedly increased IRS-1 O-GlcNAc glycosylation following hypoxia/reoxygenation. Tyrosine 91-99 insulin receptor substrate 1 Rattus norvegicus 149-154