Protein Name insulin receptor substrate 1
Organism Rattus norvegicus
Gene ID 25467
Gene Symbol


UniProt P35570 (IRS1_RAT)
Relationships Total Number of functionally related compound(s) : 330
Total Number of Articles : 669

insulin receptor substrate 1

Gene Summary

Enables several functions, including SH2 domain binding activity; protein kinase binding activity; and signaling receptor binding activity. Involved in several processes, including cellular response to peptide hormone stimulus; regulation of insulin receptor signaling pathway; and regulation of peptide hormone secretion. Located in cytosol; intracellular membrane-bounded organelle; and plasma membrane. Part of insulin receptor complex. Used to study end stage renal disease; obesity; and type 2 diabetes mellitus. Biomarker of Alzheimer's disease; non-alcoholic fatty liver disease; and osteoporosis. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; and type 2 diabetes mellitus. Orthologous to human IRS1 (insulin receptor substrate 1). [provided by Alliance of Genome Resources, Apr 2022]

  • insulin receptor substrate 1
  • IRS-1
  • pp185
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