Title : Genistein inhibits phorbol ester-induced NF-κB transcriptional activity and COX-2 expression by blocking the phosphorylation of p65/RelA in human mammary epithelial cells.

Pub. Date : 2014 Oct

PMID : 24742714






5 Functional Relationships(s)
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1 Genistein inhibits phorbol ester-induced NF-kappaB transcriptional activity and COX-2 expression by blocking the phosphorylation of p65/RelA in human mammary epithelial cells. Genistein prostaglandin-endoperoxide synthase 2 Homo sapiens
2 In the present study, we have investigated the effects of genistein on phorbol ester-induced expression of cyclooxygenase-2 (COX-2) that plays an important role in the pathophysiology of inflammation-associated carcinogenesis. Genistein prostaglandin-endoperoxide synthase 2 Homo sapiens
3 In the present study, we have investigated the effects of genistein on phorbol ester-induced expression of cyclooxygenase-2 (COX-2) that plays an important role in the pathophysiology of inflammation-associated carcinogenesis. Genistein prostaglandin-endoperoxide synthase 2 Homo sapiens
4 Pretreatment of cultured human breast epithelial (MCF10A) cells with genistein reduced COX-2 expression induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). Genistein prostaglandin-endoperoxide synthase 2 Homo sapiens
5 The above findings, taken together, suggest that genistein inhibits TPA-induced COX-2 expression in MCF10A cells by blocking ERK-mediated phosphorylation of p65 and its subsequent interaction with CBP and TBP. Genistein prostaglandin-endoperoxide synthase 2 Homo sapiens