Pub. Date : 2014 Mar 30
PMID : 24742583
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sulforaphane counteracts aggressiveness of pancreatic cancer driven by dysregulated Cx43-mediated gap junctional intercellular communication. | sulforaphane | gap junction protein alpha 1 | Homo sapiens |
| 2 | The bioactive substance sulforaphane enhanced Cx43 and E-cadherin levels, inhibited the CSC markers c-Met and CD133, improved the functional morphology of GJs and enhanced GJIC. | sulforaphane | gap junction protein alpha 1 | Homo sapiens |
| 3 | Sulforaphane altered the phosphorylation of several kinases and their substrates and inhibition of GSK3, JNK and PKC prevented sulforaphane-induced CX43 expression. | sulforaphane | gap junction protein alpha 1 | Homo sapiens |
| 4 | The sulforaphane-mediated expression of Cx43 was not correlated with enhanced Cx43 RNA expression, acetylated histone binding and Cx43 promoter de-methylation, suggesting that posttranslational phosphorylation is the dominant regulatory mechanism. | sulforaphane | gap junction protein alpha 1 | Homo sapiens |