Protein Name gap junction protein alpha 1
Organism Homo sapiens
Gene ID 2697
Gene Symbol


UniProt P17302 (CXA1_HUMAN), A0A654IBU3 (A0A654IBU3_HUMAN)
Relationships Total Number of functionally related compound(s) : 657
Total Number of Articles : 1042

gap junction protein alpha 1

Gene Summary

This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia, autosomal recessive craniometaphyseal dysplasia and heart malformations. [provided by RefSeq, May 2014]

  • gap junction alpha-1 protein
  • connexin-43
  • gap junction 43 kDa heart protein
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