Title : Crystal structures of human CtBP in complex with substrate MTOB reveal active site features useful for inhibitor design.

Pub. Date : 2014 May 2

PMID : 24657618






1 Functional Relationships(s)
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1 Crystal structures of human CtBP1 and CtBP2 in complex with MTOB and NAD(+) revealed two key features: a conserved tryptophan that likely contributes to substrate specificity and a hydrophilic cavity that links MTOB with an NAD(+) phosphate. NAD C-terminal binding protein 1 Homo sapiens