Pub. Date : 2014 May 15
PMID : 24644001
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin sensitizes EGFR-TKI-resistant human lung cancer cells in vitro and in vivo through inhibition of IL-6 signaling and EMT reversal. | Metformin | epidermal growth factor receptor | Homo sapiens |
| 2 | This study aims to investigate the effect of metformin on sensitizing EGFR-TKI-resistant human lung cancer cells in vitro and in vivo through inhibition of IL-6 signaling and EMT reversal. | Metformin | epidermal growth factor receptor | Homo sapiens |
| 3 | CONCLUSION: Metformin, generally considered nontoxic and remarkably inexpensive, might be used in combination with TKIs in patients with non-small cell lung cancer, harboring EGFR mutations to overcome TKI resistance and prolong survival. | Metformin | epidermal growth factor receptor | Homo sapiens |