Pub. Date : 2014 Apr 15
PMID : 24556618
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Early clinical trial data with rucaparib suggested that it caused sustained PARP inhibition. | rucaparib | poly (ADP-ribose) polymerase family, member 1 | Mus musculus |
| 2 | Rucaparib is retained in cells and inhibits PARP >=50% for >=72 h days after a 30-min pulse of 400 nM. | rucaparib | poly (ADP-ribose) polymerase family, member 1 | Mus musculus |
| 3 | CONCLUSIONS: Rucaparib accumulates and is retained in tumour cells and inhibits PARP for long periods such that weekly schedules have equivalent anticancer activity to daily dosing in a pre-clinical model, suggesting that clinical evaluation of alternative schedules of rucaparib should be considered. | rucaparib | poly (ADP-ribose) polymerase family, member 1 | Mus musculus |