PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24556618-2 2014 Early clinical trial data with rucaparib suggested that it caused sustained PARP inhibition. rucaparib 31-40 poly (ADP-ribose) polymerase family, member 1 Mus musculus 76-80 24556618-7 2014 Rucaparib is retained in cells and inhibits PARP >=50% for >=72 h days after a 30-min pulse of 400 nM. rucaparib 0-9 poly (ADP-ribose) polymerase family, member 1 Mus musculus 44-48 24556618-11 2014 CONCLUSIONS: Rucaparib accumulates and is retained in tumour cells and inhibits PARP for long periods such that weekly schedules have equivalent anticancer activity to daily dosing in a pre-clinical model, suggesting that clinical evaluation of alternative schedules of rucaparib should be considered. rucaparib 13-22 poly (ADP-ribose) polymerase family, member 1 Mus musculus 80-84