Pub. Date : 2014 Apr 15
PMID : 24462458
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dicoumarol sensitizes renal cell carcinoma Caki cells to TRAIL-induced apoptosis through down-regulation of Bcl-2, Mcl-1 and c-FLIP in a NQO1-independent manner. | Dicumarol | CASP8 and FADD like apoptosis regulator | Homo sapiens |
| 2 | We found that dicoumarol transcriptionally down-regulated Bcl-2 expression via inhibition of NF-kappaB and CREB activity, whereas it down-regulated Mcl-1 and c-FLIP expression at the post-translational level. | Dicumarol | CASP8 and FADD like apoptosis regulator | Homo sapiens |
| 3 | Overexpression of Bcl-2, Mcl-1, or c-FLIP overcame the dicoumarol plus TRAIL-induced apoptosis, indicating that down-regualtion of these anti-apoptotic proteins may critically contribute to the sensitizing effect of dicoumarol on TRAIL-mediated apoptosis. | Dicumarol | CASP8 and FADD like apoptosis regulator | Homo sapiens |
| 4 | Overexpression of Bcl-2, Mcl-1, or c-FLIP overcame the dicoumarol plus TRAIL-induced apoptosis, indicating that down-regualtion of these anti-apoptotic proteins may critically contribute to the sensitizing effect of dicoumarol on TRAIL-mediated apoptosis. | Dicumarol | CASP8 and FADD like apoptosis regulator | Homo sapiens |