Pub. Date : 1987 Nov
PMID : 2445297
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Anthralin inhibits elevated levels of thioredoxin reductase in psoriasis. | Anthralin | peroxiredoxin 5 | Homo sapiens |
| 2 | Because TR contains two reactive thiolate groups at its active site, this enzyme reacts with anthralin to form a covalent anthralin-TR complex causing irreversible enzyme deactivation. | Anthralin | peroxiredoxin 5 | Homo sapiens |
| 3 | Because TR contains two reactive thiolate groups at its active site, this enzyme reacts with anthralin to form a covalent anthralin-TR complex causing irreversible enzyme deactivation. | Anthralin | peroxiredoxin 5 | Homo sapiens |
| 4 | Because TR contains two reactive thiolate groups at its active site, this enzyme reacts with anthralin to form a covalent anthralin-TR complex causing irreversible enzyme deactivation. | Anthralin | peroxiredoxin 5 | Homo sapiens |
| 5 | Because TR contains two reactive thiolate groups at its active site, this enzyme reacts with anthralin to form a covalent anthralin-TR complex causing irreversible enzyme deactivation. | Anthralin | peroxiredoxin 5 | Homo sapiens |
| 6 | Keratinocyte cell cultures, grown from normal and psoriatic skin of one donor, revealed 24% and 42% inhibition of cell surface TR activity, respectively, in the presence of 2 X 10(-5)M anthralin. | Anthralin | peroxiredoxin 5 | Homo sapiens |