Title : Ursolic acid differentially modulates apoptosis in skin melanoma and retinal pigment epithelial cells exposed to UV-VIS broadband radiation.

Pub. Date : 2014 May

PMID : 24375173






1 Functional Relationships(s)
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1 These results were consistent with reduced proliferation observed in the clonogenic assay, indicating that UA treatment enhanced the phototoxicity of UVR, by modulating the activation of p53 and NF-kappaB and initiating a mitogenic response to optical radiation that triggered mitochondria-dependent apoptosis, particularly in skin melanoma cells. ursolic acid nuclear factor kappa B subunit 1 Homo sapiens