Pub. Date : 2014 Jun
PMID : 24297485
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Olmesartan blocks advanced glycation end products-induced vcam-1 gene expression in mesangial cells by restoring Angiotensin-converting enzyme 2 level. | olmesartan | angiotensin converting enzyme 2 | Homo sapiens |
| 2 | AGEs significantly increased superoxide generation, upregulated RAGE mRNA level, and decreased ACE 2 gene expression and Ang-(1-7) production in mesangial cells, all of which were blocked by olmesartan, but not by a different type of ARB, azilsartan. | olmesartan | angiotensin converting enzyme 2 | Homo sapiens |
| 3 | Our present study suggests that olmesartan could block the AGEs-induced VCAM-1 gene induction in mesangial cells by restoring the downregulated ACE 2 levels and subsequently stimulating the Ang-(1-7)-Mas receptor axis. | olmesartan | angiotensin converting enzyme 2 | Homo sapiens |