| Protein Name | angiotensin converting enzyme 2 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 59272 |
| Gene Symbol | ACE2 |
| UniProt | Q9BYF1 (ACE2_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
897
Total Number of Articles : 1205 |
Description |
angiotensin converting enzyme 2 |
| Gene Summary |
The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. ACE2 is known to be expressed in various human organs, and its organ- and cell-specific expression suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronavirus HCoV-NL63 and the human severe acute respiratory syndrome coronaviruses, SARS-CoV and SARS-CoV-2, the latter is the causative agent of coronavirus disease-2019 (COVID-19). Multiple splice variants have been found for this gene and the dACE2 (or MIRb-ACE2) splice variant has been found to be interferon inducible. [provided by RefSeq, Nov 2020] |
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