Pub. Date : 2014 Feb
PMID : 24220010
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Recently we identified the serotonin reuptake inhibitor paroxetine as an inhibitor of G protein-coupled receptor kinase 2 (GRK2) that improves cardiac performance in live animals. | Paroxetine | G protein-coupled receptor kinase 2 | Homo sapiens |
| 2 | Recently we identified the serotonin reuptake inhibitor paroxetine as an inhibitor of G protein-coupled receptor kinase 2 (GRK2) that improves cardiac performance in live animals. | Paroxetine | G protein-coupled receptor kinase 2 | Homo sapiens |
| 3 | Paroxetine exhibits up to 50-fold selectivity for GRK2 versus other GRKs. | Paroxetine | G protein-coupled receptor kinase 2 | Homo sapiens |
| 4 | Our results suggest that the selectivity of paroxetine for GRK2 largely reflects its lower affinity for adenine nucleotides. | Paroxetine | G protein-coupled receptor kinase 2 | Homo sapiens |
| 5 | Next, we designed a benzolactam derivative of paroxetine that has optimized interactions with the hinge of the GRK2 kinase domain. | Paroxetine | G protein-coupled receptor kinase 2 | Homo sapiens |