Protein Name G protein-coupled receptor kinase 2
Organism Homo sapiens
Gene ID 156
Gene Symbol

GRK2

UniProt P25098 (ARBK1_HUMAN), A0A0S2Z392 (A0A0S2Z392_HUMAN)
Relationships Total Number of functionally related compound(s) : 199
Total Number of Articles : 291
Description

G protein-coupled receptor kinase 2

Gene Summary

This gene encodes a member of the G protein-coupled receptor kinase family of proteins. The encoded protein phosphorylates the beta-adrenergic receptor as well as a wide range of other substrates including non-GPCR cell surface receptors, and cytoskeletal, mitochondrial, and transcription factor proteins. Data from rodent models supports a role for this gene in embryonic development, heart function and metabolism. Elevated expression of this gene has been observed in human patients with heart failure and Alzheimer's disease. [provided by RefSeq, Sep 2017]

synonyms
  • beta-adrenergic receptor kinase 1
  • adrenergic beta receptor kinase 1
  • beta-ARK-1
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Properties