Protein Name | G protein-coupled receptor kinase 2 |
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Organism | Homo sapiens |
Gene ID | 156 |
Gene Symbol | GRK2 |
UniProt | P25098 (ARBK1_HUMAN), A0A0S2Z392 (A0A0S2Z392_HUMAN) |
Relationships |
Total Number of functionally related compound(s) :
199
Total Number of Articles : 291 |
Description |
G protein-coupled receptor kinase 2 |
Gene Summary |
This gene encodes a member of the G protein-coupled receptor kinase family of proteins. The encoded protein phosphorylates the beta-adrenergic receptor as well as a wide range of other substrates including non-GPCR cell surface receptors, and cytoskeletal, mitochondrial, and transcription factor proteins. Data from rodent models supports a role for this gene in embryonic development, heart function and metabolism. Elevated expression of this gene has been observed in human patients with heart failure and Alzheimer's disease. [provided by RefSeq, Sep 2017] |
synonyms |
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Properties | |