PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24220010-1 2014 Recently we identified the serotonin reuptake inhibitor paroxetine as an inhibitor of G protein-coupled receptor kinase 2 (GRK2) that improves cardiac performance in live animals. Paroxetine 56-66 G protein-coupled receptor kinase 2 Homo sapiens 86-121 24220010-1 2014 Recently we identified the serotonin reuptake inhibitor paroxetine as an inhibitor of G protein-coupled receptor kinase 2 (GRK2) that improves cardiac performance in live animals. Paroxetine 56-66 G protein-coupled receptor kinase 2 Homo sapiens 123-127 24220010-2 2014 Paroxetine exhibits up to 50-fold selectivity for GRK2 versus other GRKs. Paroxetine 0-10 G protein-coupled receptor kinase 2 Homo sapiens 50-54 24220010-6 2014 Our results suggest that the selectivity of paroxetine for GRK2 largely reflects its lower affinity for adenine nucleotides. Paroxetine 44-54 G protein-coupled receptor kinase 2 Homo sapiens 59-63 24220010-8 2014 Next, we designed a benzolactam derivative of paroxetine that has optimized interactions with the hinge of the GRK2 kinase domain. Paroxetine 46-56 G protein-coupled receptor kinase 2 Homo sapiens 111-115