Title : Activities of multiple cancer-related pathways are associated with BRAF mutation and predict the resistance to BRAF/MEK inhibitors in melanoma cells.

Pub. Date : 2014

PMID : 24200969






2 Functional Relationships(s)
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1 Further analysis of 46 melanoma cell lines that harbored BRAF mutation showed that 7 pathways, including TNFalpha, EGFR, IFNalpha, hypoxia, IFNgamma, STAT3, and MYC, were significantly differently expressed in AZD6244-resistant compared with responsive melanoma cells. AZD 6244 B-Raf proto-oncogene, serine/threonine kinase Homo sapiens
2 A SVM classifier built on this 7-pathway activation pattern correctly predicted the response of 10 BRAF-mutated melanoma cell lines to the MEK inhibitor AZD6244 in our experiments. AZD 6244 B-Raf proto-oncogene, serine/threonine kinase Homo sapiens