Pub. Date : 2014
PMID : 24189249
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | An in situ single-pass intestinal perfusion study in rats with the P-gp inhibitor verapamil or quinidine and an ATPase assay with human P-gp membranes indicated that lumefantrine is a substrate of P-gp which limits its intestinal absorption. | Verapamil | ATP-binding cassette, subfamily B (MDR/TAP), member 1B | Rattus norvegicus |
2 | The increase in bioavailability of lumefantrine could be due to inhibition of P-gp and/or cytochrome P450 3A in the intestine/liver by verapamil. | Verapamil | ATP-binding cassette, subfamily B (MDR/TAP), member 1B | Rattus norvegicus |
3 | Thus, the increase in lumefantrine bioavailability with verapamil is attributed in part to the P-gp-inhibitory ability of verapamil. | Verapamil | ATP-binding cassette, subfamily B (MDR/TAP), member 1B | Rattus norvegicus |
4 | Thus, the increase in lumefantrine bioavailability with verapamil is attributed in part to the P-gp-inhibitory ability of verapamil. | Verapamil | ATP-binding cassette, subfamily B (MDR/TAP), member 1B | Rattus norvegicus |