Pub. Date : 2013 Oct
PMID : 24156425
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | [COX-2 inhibitor celecoxib can suppress the proliferation of FLT3-ITD positive acute myeloid leukemia cells with prominent down regulation of MEK/MCL-1 expression in vitro]. | Celecoxib | mitogen-activated protein kinase kinase 7 | Homo sapiens |
| 2 | The proliferation inhibition effect of Celecoxib with different doses on the FLT3-ITD positive cells MV4-11 and the FLT3-ITD negative K562 cells was detected by CCK-8 method, the cell apoptosis was determined by flow cytometry, and the MEK, Mcl-1, pAKT expression was tested by Western blot. | Celecoxib | mitogen-activated protein kinase kinase 7 | Homo sapiens |
| 3 | Western blot showed that Celecoxib down-regulated the expression of MEK and Mcl-1 but did not change the expression of pAKT obviously on MV4-11 cells, while the expression of Mcl-1 was reduced a little, but no obvious change were found in the expression of MEK and pAKT on K562 cells. | Celecoxib | mitogen-activated protein kinase kinase 7 | Homo sapiens |
| 4 | Western blot showed that Celecoxib down-regulated the expression of MEK and Mcl-1 but did not change the expression of pAKT obviously on MV4-11 cells, while the expression of Mcl-1 was reduced a little, but no obvious change were found in the expression of MEK and pAKT on K562 cells. | Celecoxib | mitogen-activated protein kinase kinase 7 | Homo sapiens |
| 5 | It is concluded that the Celecoxib can inhibit the proliferation of FLT3-ITD positive AML cells distinctly, and the potential mechanism may be related to the inhibition of the MEK/Mcl-1 signaling pathway. | Celecoxib | mitogen-activated protein kinase kinase 7 | Homo sapiens |