Pub. Date : 2013 Aug
PMID : 24137201
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Anti-inflammatory effects of escin are correlated with the glucocorticoid receptor/NF-kappaB signaling pathway, but not the COX/PGF2alpha signaling pathway. | Escin | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 | Mus musculus |
| 2 | However, our previous studies demonstrated that escin did not increase the secretion of GCs, but instead elevated the protein expression of the GC receptor (GR), which may have repressed nuclear factor (NF)-kappaB-mediated gene expression. | Escin | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 | Mus musculus |
| 3 | The aim of this study was to determine the functions of NF-kappaB and PGF2alpha with regard to the anti-inflammatory effect of escin. | Escin | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 | Mus musculus |
| 4 | Furthermore, we investigated the function of NF-kappaB with regard to the anti-inflammatory effect exerted by escin in lipopolysaccharide (LPS)-treated mice, and demonstrated that escin significantly inhibited the expression of NF-kappaB. | Escin | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 | Mus musculus |
| 5 | Furthermore, we investigated the function of NF-kappaB with regard to the anti-inflammatory effect exerted by escin in lipopolysaccharide (LPS)-treated mice, and demonstrated that escin significantly inhibited the expression of NF-kappaB. | Escin | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 | Mus musculus |
| 6 | Furthermore, we investigated the function of NF-kappaB with regard to the anti-inflammatory effect exerted by escin in lipopolysaccharide (LPS)-treated mice, and demonstrated that escin significantly inhibited the expression of NF-kappaB. | Escin | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 | Mus musculus |
| 7 | These results suggest that escin has a GC-like anti-inflammatory effect, and that its mechanisms may be correlated with the GC receptor/NF-kappaB signaling pathway, but not the COX/PGF2alpha signaling pathway. | Escin | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 | Mus musculus |