PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24137201-0 2013 Anti-inflammatory effects of escin are correlated with the glucocorticoid receptor/NF-kappaB signaling pathway, but not the COX/PGF2alpha signaling pathway. Escin 29-34 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 83-92 24137201-3 2013 However, our previous studies demonstrated that escin did not increase the secretion of GCs, but instead elevated the protein expression of the GC receptor (GR), which may have repressed nuclear factor (NF)-kappaB-mediated gene expression. Escin 48-53 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 187-213 24137201-4 2013 The aim of this study was to determine the functions of NF-kappaB and PGF2alpha with regard to the anti-inflammatory effect of escin. Escin 127-132 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 56-65 24137201-8 2013 Furthermore, we investigated the function of NF-kappaB with regard to the anti-inflammatory effect exerted by escin in lipopolysaccharide (LPS)-treated mice, and demonstrated that escin significantly inhibited the expression of NF-kappaB. Escin 110-115 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 45-54 24137201-8 2013 Furthermore, we investigated the function of NF-kappaB with regard to the anti-inflammatory effect exerted by escin in lipopolysaccharide (LPS)-treated mice, and demonstrated that escin significantly inhibited the expression of NF-kappaB. Escin 180-185 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 45-54 24137201-8 2013 Furthermore, we investigated the function of NF-kappaB with regard to the anti-inflammatory effect exerted by escin in lipopolysaccharide (LPS)-treated mice, and demonstrated that escin significantly inhibited the expression of NF-kappaB. Escin 180-185 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 228-237 24137201-9 2013 These results suggest that escin has a GC-like anti-inflammatory effect, and that its mechanisms may be correlated with the GC receptor/NF-kappaB signaling pathway, but not the COX/PGF2alpha signaling pathway. Escin 27-32 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 136-145