Pub. Date : 2014 Apr
PMID : 24089076
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The authors aimed to evaluate the additional contribution of POR*28 to early tacrolimus disposition in pediatric kidney transplant recipients. | Tacrolimus | cytochrome p450 oxidoreductase | Homo sapiens |
| 2 | RESULTS: CYP3A5 expressers carrying at least 1 POR*28 allele had on average 18.3% lower tacrolimus predose concentrations and 20.2% lower concentration/dose ratios compared with CYP3A5 expressers with POR*1/*1 genotype (P = 0.002 and P = 0.001, respectively). | Tacrolimus | cytochrome p450 oxidoreductase | Homo sapiens |
| 3 | CONCLUSIONS: In this small cohort of pediatric kidney transplant recipients, POR*28 genotype seems to explain part of the variability found in tacrolimus disposition, in addition to age and CYP3A5 genotype. | Tacrolimus | cytochrome p450 oxidoreductase | Homo sapiens |