PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24089076-3 2014 The authors aimed to evaluate the additional contribution of POR*28 to early tacrolimus disposition in pediatric kidney transplant recipients. Tacrolimus 77-87 cytochrome p450 oxidoreductase Homo sapiens 61-64 24089076-6 2014 RESULTS: CYP3A5 expressers carrying at least 1 POR*28 allele had on average 18.3% lower tacrolimus predose concentrations and 20.2% lower concentration/dose ratios compared with CYP3A5 expressers with POR*1/*1 genotype (P = 0.002 and P = 0.001, respectively). Tacrolimus 88-98 cytochrome p450 oxidoreductase Homo sapiens 47-50 24089076-8 2014 CONCLUSIONS: In this small cohort of pediatric kidney transplant recipients, POR*28 genotype seems to explain part of the variability found in tacrolimus disposition, in addition to age and CYP3A5 genotype. Tacrolimus 143-153 cytochrome p450 oxidoreductase Homo sapiens 77-80